The Role of Growth Differentiation Factors 11 and 15 (GDF11, GDF15), Eotaxin-1 (CCL11) and Junctional Adhesion Molecule a (JAM-A) in the Regulation of Blood Pressure in Women with Essential Hypertension

Evaluation of biomarkers of arterial hypertension (AH) could be considered to be useful as early, more reliable and accurate diagnostic indicators for AH than simply measuring of blood pressure (BP) in routine clinical practice, especially at early stages of hypertension. For instance, an increased level of a soluble protein junctional adhesion molecule-A (JAM-A) was previously found to be associated with human hypertension [1,2]. JAM-A upregulation may be triggered by AT [1] receptor-mediated signaling and therefore it is suggested that JAM-A may have a prognostic and possibly a pathogenic role in the development of AH [3]. Recently, Bhat SA et al. [4] found that in patients with AH the expression of adhesion molecules (including JAM-A) on brain endothelium is increased [4].